Anyone who has followed it has seen huge returns. It also enters Championship Week 2021 on a 42-28 run on all top-rated college football side picks. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. The SportsLine Projection Model simulates every FBS college football game 10,000 times. Michigan picks or college football predictions, you need to see what the SportsLine Projection Model has to say. Iowa odds, and the over-under for total points scored is set at 43.5. The Wolverines are the 12-point favorites in Caesars Sportsbook's latest Michigan vs. 2 in the nation after a 6-0 start but promptly lost consecutive games. Iowa (10-2) beat Nebraska last Friday for its fourth straight win, but it is seeking this title to salvage what was shaping up as a dream season. Neither team has won a conference championship since 2004, when they shared the title. Now they will need to avoid a letdown for a chance to play for their first national championship since 1997, and their 12th overall. The Wolverines (11-1) moved up to the second spot in the College Football Playoff rankings with a 42-27 victory against Ohio State last Saturday. 2 Michigan Wolverines are eyeing a national-title run, but first they need to beat the 13th-ranked Iowa Hawkeyes in the 2021 Big Ten Championship Game on Saturday.